The Abnormal Hemoglobin Syndromes
نویسنده
چکیده
By IRwIN 1\i. WEINSTEIN, CARROLL L. SPURLING, HERMAN I’tLEIN AND THOMAS F. XECHELES I x PREVIOUS PUBLICATIONS,’ ,2 1e have reported that tagging human erythrocytes with radioactive chromium in the form of Na2Cr”O4 affords a simple, rapid and reproducible method for studying the survival of erythrocytes in normal subjects and patients with various hernatologic disturbances. By this method the one-half survival time of Cr” tagged red blood cells is 33.1 ± 3.2 days. This time refers to the apparent one-half survival, i.e., the curves are not corrected for chromium “leakage,” a phenomenon which occurs at the rate of approximately one per cent of the remaining radioactivity per day, but which does not interfere with establishing an accurate quantitative relationship between normal and abnormal survival curves. Of the various abnormal red cells tested thus far, “leakage” occurs at the same rate with abnormal as with normal red cells. In this paper we are reporting the hematologic findings including Cr” red cell survival studies in a group of patients with abnormal hemoglobin syndromes. Although a few reports3 ‘ ‘ ‘ on the survival time of erythrocytes containing one or a combination of the recently identified abnormal hemoglobins have appeared in the literature to date, to our knowledge this is the first such report using the Cr” technique.
منابع مشابه
The Relationship of Uterine Artery Doppler Velocimetry Findings and Hemoglobin Concentration with Pregnancy Outcomes in Pre-eclampsia
Abstract Background: Epidemiologic studies have shown the relationship of maternal hemoglobin level and abnormal findings in uterine Doppler sonography with pregnancy- related complications. In this study, we evaluated the relationship of uterine artery Doppler velocimetry findings and hemoglobin level with the outcomes of pregnancy in women with preeclampsi...
متن کاملUnusual presentation of a patient with hemoglobin Constant Spring and immune hemolytic anemia
Abstract Introduction: Hemoglobin Constant Spring (Hb CS), a abnormal Hb characterized by elongated α-globin chain resulting from mutations of the termination codon in the α2 - globin gene , is the most common nondelitional α-thalassemic mutation and is an important cause of HbH like disease in Southeast Asia. Case Report: A 9- years-old female with immune hemolytic anemia and splenomegally...
متن کاملA new hereditary hemoglobinopathy (the Lepore trait) and its interaction with thalassemia trait.
By PARK S. GERALD AND Louis K. DIAMOND T HIS REPORT details our experiences with a new hemoglobinopathy which we have named the “Lepore trait.” This condition was discovered during a recent survey of the relatives of thalassemia major children.1 The mother of a child with clinical thalassemia major was found to possess a new abnormal hemoglobin (which we have named the Lepore hemoglobin) demons...
متن کاملReciprocal relationship of hemoglobins A2 and F in beta chain thalassemias, a key to the genetic control of hemoglobin F.
By WOLF W. ZUELZER, ABNER R. ROBINSON AND CLIFFORD R. Booian T HE EXISTENCE of more than one kind of gene capable of producing the stigmata of thalassemia was first suggested’ as a possible explanation for the surprisingly wide spectrum of hematologic phenotypes observed in syndromes thought to result from the combination of a gene for thalassemia with a gene for one of the abnormal hemoglobins...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005